Saturday, March 28, 2009
Zinc May Enhance Effects of Anti-Depressant Medications
In double blind placebo controlled study involving 60 patients with major depression (without any psychotic symptoms), treatment with zinc (25 mg/day) was added to standard anti-depressant drug therapy (imipramine, 140 mg/day). Addition of zinc significantly reduced depression scores and improved treatment outcomes in anti-depressant-resistant patients, as compared to supplementation with a placebo. These results support results from a preliminary clinical report suggesting that supplementation with zinc may augment the effects of anti-depressant drug therapy. The authors conclude, "Zinc supplementation augments the efficacy and speed of onset of therapeutic response to imipramine treatment, particularly in patients previously nonresponsive to antidepressant pharmacotherapies. These data suggest the participation of disturbed zinc/glutamatergic transmission in the pathophysiology of drug resistance."
Sunday, March 15, 2009
Teenage Boys Who Eat Fish Achieve Higher IQ Scores
Fifteen-year-old males who ate fish at least once a week displayed higher cognitive skills at the age of 18 than those who it ate it less frequently, according to a study of nearly 4,000 teenagers published in the March issue of Acta Paediatrica.
Eating fish once a week was enough to increase combined, verbal, and visual spatial intelligence scores by an average of six per cent, while eating fish more than once a week increased them by just under 11 percent.
"We found a clear link between frequent fish consumption and higher scores when the teenagers ate fish at least once a week" says Professor Kjell Torén from the Sahlgrenska Academy at the University of Gothenburg, one of the senior scientists involved in the study. "When they ate fish more than once a week the improvement almost doubled.
"A number of studies have already shown that fish can help neurodevelopment in infants, reduce the risk of impaired cognitive function from middle age onwards and benefit babies born to women who ate fish during pregnancy" says Professor Torén. "However we believe that this is the first large-scale study to explore the effect on adolescents."
"The most widely held theory is that it is the long-chain polyunsaturated fatty acids found in fish that have positive effects on
cognitive performance" explains Professor Torén. Other theories highlight their vascular and anti-inflammatory properties and their role in suppressing cytokines, chemicals that can affect the immune system."
Eating fish once a week was enough to increase combined, verbal, and visual spatial intelligence scores by an average of six per cent, while eating fish more than once a week increased them by just under 11 percent.
"We found a clear link between frequent fish consumption and higher scores when the teenagers ate fish at least once a week" says Professor Kjell Torén from the Sahlgrenska Academy at the University of Gothenburg, one of the senior scientists involved in the study. "When they ate fish more than once a week the improvement almost doubled.
"A number of studies have already shown that fish can help neurodevelopment in infants, reduce the risk of impaired cognitive function from middle age onwards and benefit babies born to women who ate fish during pregnancy" says Professor Torén. "However we believe that this is the first large-scale study to explore the effect on adolescents."
"The most widely held theory is that it is the long-chain polyunsaturated fatty acids found in fish that have positive effects on
cognitive performance" explains Professor Torén. Other theories highlight their vascular and anti-inflammatory properties and their role in suppressing cytokines, chemicals that can affect the immune system."
Monday, March 2, 2009
Friendships Among Women Counteract Stress
UCLA STUDY ON FRIENDSHIP AMONG WOMEN
By Gale Berkowitz
A landmark UCLA study suggests friendships between women are special. They shape who we are and who we are yet to be. They soothe our tumultuous inner world, fill the emotional gaps in our marriage, and help us remember who we really are. By the way, they may do even more.
Scientists now suspect that hanging out with our friends can actually counteract the kind of stomach-quivering stress most of us experience on a daily basis. A landmark UCLA study suggests that women respond to stress with a cascade of brain chemicals that cause us to make and maintain friendships with other women. It's a stunning find that has turned five decades of stress research---most of it on men---upside down. "Until this study was published, scientists generally believed that when people experience stress, they trigger a hormonal cascade that revs the body to either stand and fight or flee as fast as possible," explains Laura Cousino Klein, Ph.D., now an Assistant Professor of Biobehavioral Health at Penn State University and one of the study's authors. "It's an ancient survival mechanism left over from the time we were chased across the planet by saber-toothed tigers.
Now the researchers suspect that women have a larger behavioral repertoire than just "fight or flight." "In fact," says Dr. Klein,"it seems that when the hormone oxytocin is released as part of the stress responses in a woman, it buffers the "fight or flight" response and encourages her to tend children and gather with other women instead. When she actually engages in this tending or befriending, studies suggest that more oxytocin is released, which further counters stress and produces a
calming effect. This calming response does not occur in men", says Dr. Klein, "because testosterone---which men produce in high levels when they're under stress---seems to reduce the effects of oxytocin. Estrogen", she adds, "seems to enhance it."
The discovery that women respond to stress differently than men was made in a classic "aha!" moment shared by two women scientists who were talking one day in a lab at UCLA. "There was this joke that when the women who worked in the lab were stressed, they came in, cleaned the lab, had coffee, and bonded", says Dr. Klein. "When the men were stressed,
they holed up somewhere on their own. I commented one day to fellow researcher Shelley Taylor that nearly 90% of the stress research is on males. I showed her the data from my lab, and the two of us knew instantly that we were onto something."
The women cleared their schedules and started meeting with one scientist after another from various research specialties. Very quickly, Drs. Klein and Taylor discovered that by not including women in stress research, scientists had made a huge mistake: The fact that women respond to stress differently than men has significant implications for our health.
It may take some time for new studies to reveal all the ways that oxytocin encourages us to care for children and hang out with other women, but the "tend and befriend" notion developed by Drs. Klein and Taylor may explain why women consistently outlive men. Study after study has found that social ties reduce our risk of disease by lowering blood pressure, heart rate, and cholesterol. "There's no doubt," says Dr. Klein, "that friends are helping us live." In one study, for example,
researchers found that people who had no friends increase d their risk of death over a 6-month period. In another study, those who had the most friends over a 9-year period cut their risk of death by more than 60%.
Friends are also helping us live better. The famed Nurses' Health Study from Harvard Medical School found that the more friends women had, the less likely they were to develop physical impairments as they aged, and the more likely they were to be leading a joyful life. In fact, the results were so significant, the researchers concluded, that not having close friends or confidantes was as detrimental to your health as smoking or carrying extra weight! And that's not all! When the researchers looked at how well the women functioned after the death of their spouse, they found that even in the face of this biggest stressor of all, those women who had a close friend confidante were more likely to survive the experience without any new physical impairments or permanent loss of vitality. Those without friends were not always so fortunate.
Yet if friends counter the stress that seems to swallow up so much of our life these days, if they keep us healthy and even add years to our life, why is it so hard to find time to be with them? That's a question that also troubles researcher Ruthellen Josselson, Ph.D., co-author of "Best Friends: The Pleasures and Perils of Girls' and Women's Friendships (Three Rivers Press, 1998). "Every time we get overly busy with work and family, the first thing we do is let go of friendships with other women,"
explains Dr. Josselson. "We push them right to the back burner. That's really a mistake because women are such a source of strength to each other. We nurture one another. And we need to have unpressured space in which we can do the special kind of talk that women do when they're with other women. It's a very healing experience."
Taylor, S. E., Klein, L.C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. Female Responses to Stress: Tend and Befriend, Not Fight or Flight
By Gale Berkowitz
A landmark UCLA study suggests friendships between women are special. They shape who we are and who we are yet to be. They soothe our tumultuous inner world, fill the emotional gaps in our marriage, and help us remember who we really are. By the way, they may do even more.
Scientists now suspect that hanging out with our friends can actually counteract the kind of stomach-quivering stress most of us experience on a daily basis. A landmark UCLA study suggests that women respond to stress with a cascade of brain chemicals that cause us to make and maintain friendships with other women. It's a stunning find that has turned five decades of stress research---most of it on men---upside down. "Until this study was published, scientists generally believed that when people experience stress, they trigger a hormonal cascade that revs the body to either stand and fight or flee as fast as possible," explains Laura Cousino Klein, Ph.D., now an Assistant Professor of Biobehavioral Health at Penn State University and one of the study's authors. "It's an ancient survival mechanism left over from the time we were chased across the planet by saber-toothed tigers.
Now the researchers suspect that women have a larger behavioral repertoire than just "fight or flight." "In fact," says Dr. Klein,"it seems that when the hormone oxytocin is released as part of the stress responses in a woman, it buffers the "fight or flight" response and encourages her to tend children and gather with other women instead. When she actually engages in this tending or befriending, studies suggest that more oxytocin is released, which further counters stress and produces a
calming effect. This calming response does not occur in men", says Dr. Klein, "because testosterone---which men produce in high levels when they're under stress---seems to reduce the effects of oxytocin. Estrogen", she adds, "seems to enhance it."
The discovery that women respond to stress differently than men was made in a classic "aha!" moment shared by two women scientists who were talking one day in a lab at UCLA. "There was this joke that when the women who worked in the lab were stressed, they came in, cleaned the lab, had coffee, and bonded", says Dr. Klein. "When the men were stressed,
they holed up somewhere on their own. I commented one day to fellow researcher Shelley Taylor that nearly 90% of the stress research is on males. I showed her the data from my lab, and the two of us knew instantly that we were onto something."
The women cleared their schedules and started meeting with one scientist after another from various research specialties. Very quickly, Drs. Klein and Taylor discovered that by not including women in stress research, scientists had made a huge mistake: The fact that women respond to stress differently than men has significant implications for our health.
It may take some time for new studies to reveal all the ways that oxytocin encourages us to care for children and hang out with other women, but the "tend and befriend" notion developed by Drs. Klein and Taylor may explain why women consistently outlive men. Study after study has found that social ties reduce our risk of disease by lowering blood pressure, heart rate, and cholesterol. "There's no doubt," says Dr. Klein, "that friends are helping us live." In one study, for example,
researchers found that people who had no friends increase d their risk of death over a 6-month period. In another study, those who had the most friends over a 9-year period cut their risk of death by more than 60%.
Friends are also helping us live better. The famed Nurses' Health Study from Harvard Medical School found that the more friends women had, the less likely they were to develop physical impairments as they aged, and the more likely they were to be leading a joyful life. In fact, the results were so significant, the researchers concluded, that not having close friends or confidantes was as detrimental to your health as smoking or carrying extra weight! And that's not all! When the researchers looked at how well the women functioned after the death of their spouse, they found that even in the face of this biggest stressor of all, those women who had a close friend confidante were more likely to survive the experience without any new physical impairments or permanent loss of vitality. Those without friends were not always so fortunate.
Yet if friends counter the stress that seems to swallow up so much of our life these days, if they keep us healthy and even add years to our life, why is it so hard to find time to be with them? That's a question that also troubles researcher Ruthellen Josselson, Ph.D., co-author of "Best Friends: The Pleasures and Perils of Girls' and Women's Friendships (Three Rivers Press, 1998). "Every time we get overly busy with work and family, the first thing we do is let go of friendships with other women,"
explains Dr. Josselson. "We push them right to the back burner. That's really a mistake because women are such a source of strength to each other. We nurture one another. And we need to have unpressured space in which we can do the special kind of talk that women do when they're with other women. It's a very healing experience."
Taylor, S. E., Klein, L.C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. Female Responses to Stress: Tend and Befriend, Not Fight or Flight
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